Severe acute anemia attributable to concomitant occurrence of AIHA with PRCA induced by parvovirus B19 infection
نویسنده :
تاریخ انتشار : 1397/06/04
A 10-year-old, previously healthy girl presented with asthenia
and fever of 3 days’ duration. Initial investigations revealed mild
leukopenia and severe hemolytic anemia (hemoglobin 5 4.9
mg/dL) with a markedly positive direct Coombs test. However,
the absolute reticulocyte count was unexpectedly low, necessitating
a bone marrow aspiration. It revealed marked hypoplasia
of erythroid lineage that was mainly represented by
scattered giant proerythroblasts showing intranuclear inclusions
highly suggestive of underlying parvovirus B19 infection (panel A;
May-Grunwald Giemsa stain, original magnification 31000).
Activated macrophages showing hemophagocytosis were also
noted as highlighted on the iron stain preparation (panel B; Perls’
Prussian blue stain, original magnification 31000).