مقالات

Effect of Allium sativum Extract on Erythromycin and Methicillin Resistant Bacteria Isolated from Hospital Operating Room

نویسنده :
تاریخ انتشار : 1395/10/12
Background: This study aimed to evaluate antibacterial effect of Allium sativum, garlic extract on erythromycin and methicillin resistant bacteria isolated from an operating room in a teaching hospital in Tehran, I.R. Iran. Methods: The antibacterial effect of garlic extract was investigated on 70 bacterial strains. The selected isolates were resistant to erythromycin and or methicillin, which were isolated from an operating room. Antibiotic sensitivity was done using an agar well diffusion procedure and either a micro dilution method. Each of the bacterial strains were exposed to concentrations of 4, 8, 12, 16, 20 and 24 µg/ml of garlic extract, separately. The growth rate of the strains was determined by measurement of the inhibition zone diameter, colony count and either by measurement of the optical density. Results: The results showed that 70 (100%) of the strains in agar well diffusion method were sensitive to 4- 12 µg/ml of garlic extract with MIC 8 µg/ml. While, the results of micro dilution method showed that 40 out of 70 strains were MIC ≥ 12 µg/ml for GE. Conclusion: The results of this study indicated that the MIC and minimum bactericidal concentration of garlic extract were 8 µg/ml and 16 µg/ml, respectively. These finding indicated that garlic extract inhibit the growth of erythromycin and methicillin resistant bacterial strains.

Contamination of Tap Water with Pseudomonas aeruginosa, Legionella pneumophila, and Escherichia coli in Guilan, Iran

نویسنده :
تاریخ انتشار : 1395/10/12
Background: River and underground waters are main sources of tap water in Guilan, Iran. Overland wastes move into rivers during periods of heavy or extended rain that is very common in the area. Pseudomonas aeruginosa, Legionella pneumophila, and Escherichia coli are main human pathogens with water source. This study is designed to determine the load of these bacteria in main water supplies of the area. Methods: Samples were collected directly into sterile containers, concentrated by centrifuge, inoculated in enrichment medium and incubated for 3-4 days. DNA was extracted by using commercial kit. Several rounds of PCR was performed to search P. aeroginosa, integron I, Metallo-β-lactamases gene, L. pneumophila, mip gene, and E. coli. Results: About 92.0% of the samples showed bacterial contamination as revealed by PCR with primers of 16S rRNAgene, 9.5% of the samples had L. pneumophila, and 11,1% had Pseudomonas aeruginosa, but Escherichia coli was not detected. We found the mip gene in 66.6% of the samples with L. pneumophila. Metallo-β-lactamasesgene was found in 11.1% of all samples. We also found Integrin 1 in 28.5% of the samples with P. aeruginosa. Conclusion: This study indicates that in spite of chlorination, total bacterial contamination of pot waters in the area is high and contamination with L. pneumophila and P. aeroginosa is considerable. It might be related to the biofilm formation and the growth of water microflora. It seems that free residual chlorine is ineffective. We suggest a more effective decontamination procedure based on modern technology.

Phenotypic and Genotypic Detection of Metallo-Beta-Lactamases among Imipenem Resistant Gram Negative Isolates

نویسنده :
تاریخ انتشار : 1395/10/12
Background: Imipenem-resistant gram negative bacteria, resulting from metallo-beta-lactamase (MBLs)-producing strains have been reported to be among the important causes of nosocomial infections and of serious therapeutic problem worldwide. Because of their broad range, potent carbapenemase activity and resistance to inhibitors, these enzymes can confer resistance to almost all beta-lactams. The prevalence of metallo-beta-lactamase among imipenem-resistant Acinetobacter spp., Pseudomonas spp. and Enerobacteriaceae isolates is determined. Methods: In this descriptive study 864 clinical isolates of Acinetobacter spp., Pseudomonas spp. and Enterobacteriaceae, were initially tested for imipenem susceptibility. The metallo-beta-lactamase production was detected using combined disk diffusion, double disk synergy test, and Hodge test. Then all imipenem resistant isolates were tested by PCR for imp, vim and ndm genes. Results: Among 864 isolates, 62 (7.17 %) were imipenem-resistant. Positive phonetypic test for metallo-beta-lactamase was 40 (64.5%), of which 24 (17.1%) and 16 (9.2%) isolates were Acinetobacter spp. and Pseudomonas spp., respectively. By PCR method 30 (48.4%) of imipenem resistant Acinetobacter, and Pseudomonas isolates were positive for MBL-producing genes. None of the Enterobacteriaceae isolates were positive for metallo-beta-lactamase activity. Conclusion: The results of this study are indicative of the growing number of nosocomial infections associated with multidrug-resistant gram negative bacteria in this region leading to difficulties in antibiotic therapy. Thereby, using of phenotypic methods can be helpful for management of this problem.

آسیبهاي شغلی-باقرعلی فاضلی، فاطمه آهکی

نویسنده :
تاریخ انتشار : 1395/10/12
هر وقت موضوع آسیبهاي شغلی مطرح میشود توجه همکاران بیشتر به سمت انتقال بیماريهاي عفونی که یکی از مهمترین موارد آسیب شغلی در آزمایشگاه تشخیص طبی است، معطوف میشود و آنچه در درجه اول ذهن ایشان را درگیر میکند نقش نیدل و لانست و تیغ بیستوري و از این قبیل وسایل است که البته بجا و درست است ولی نباید فراموش شود در شغل ما خطر همهجا در کمین است؛ کلیه سطوح اشیاء، وسایل آزمایشگاه، کابینتها، دستگیرهها و غیره آلوده محسوب میشوند و اگر داراي لبهها و زوائد تیز و برنده باشند خطري جدي به شمار میآیند. حتی بریده شدن پوست و دستکش آلوده توسط وسایل استریل یک خطر جدي محسوب میشود و در مورد وسایل و سطوح آلوده این خطر جديتر است و حتی کلیه همکاران در زندگی روزمره و همچنین تمرینها و ورزشهاي مورد علاقهشان باید مواظب سلامت پوست دستانشان باشند زیرا در شغل ما، پوست دست جایگاه ویژهاي دارد.