A Nontoxic Case of Vitamin D Toxicity ,Sutirtha Chakraborty
نویسنده :
تاریخ انتشار : 1395/10/09
Vitamin D toxicity also known as hypervitaminosis D was previously
believed to be rare. But with an increase in vitamin D supplementation
several cases have been reported in literature. Fat soluble vitamins
like Vitamin D, due to their ability to accumulate in the body, have a
higher potential for toxicity than water soluble vitamins. The main
clinical consequence of vitamin D toxicity is hypercalcemia. In this
report we describe an adult female patient who developed very
high serum Vitamin D levels (746 ng/mL, RI: 20 to 50) as a result of
medication error. Inspite of such high serum concentrations the patient
was without any clinical symptoms and had normal serum calcium.
We critically discuss the mechanism of toxicity and hypothesize
the possible molecular/metabolic factors which might have been
responsible for this nontoxic presentation. This case study highlights
the fact that physicians need to consider the risk of medication errors
while prescribing Vitamin D therapy. Clinical trials to study Vitamin D
toxicity in humans is not possible ethically. Thus the evidence base
regarding the safety profile of Vitamin D supplementation in humans
has been build through case reports. This review of the paradoxical
clinico-laboratory manifestation of hypervitaminosis D could possibly
contribute to existing literature.